Let’s see, some good ways to destroy humanity by aliens:

1. Stop your commodity market from being supplied by us, then there would be no profit to provide incentive to other “higher beings” for our continued existence.
2. Stop artificially enhancing our immune systems by dumping diseases and contagions on us. Because what does kills us, also makes us stronger.
3. Stop providing and propping up ”leaders” and influencers to control our so-called disruptive behavior.
4. Stop hindering our scientists from developing dangerous fusion technology that we could blow ourselves up with.

Just a few brainstorming ideas that came to mind.